← Shelf·GHRH analog (29-residue N-terminal fragment)·XVII.
Sermorelin.
A synthetic peptide corresponding to the first 29 amino acids of human growth-hormone-releasing hormone (GHRH 1-29 NH₂) — the shortest N-terminal fragment retaining full biological activity at the GHRH receptor. Was previously FDA-approved as a prescription drug for pediatric growth-hormone deficiency; that branded formulation was commercially discontinued in the United States in 2008 (withdrawn from the market, not for safety reasons).
GHRH is a hormone your hypothalamus produces to signal the pituitary to release growth hormone. Sermorelin is the truncated synthetic analog researchers use when they want the same receptor engagement in a lab or clinical study.
One of the older, more thoroughly-characterized secretagogues on the shelf. Two decades of clinical trial data exists — mostly for the FDA-labeled pediatric indication, plus a substantial off-label prescribing history at compounding-pharmacy clinics. The primary literature is real; the wellness narrative that sits on top of it is loosely coupled to the label.
Straight talk
Straight talk: sermorelin has a long clinical record, but that record is anchored to a specific FDA indication that is not what most people search this compound for. Whether the research-grade compound in a given vial IS the same molecule as the FDA-approved drug of the same INN is exactly what a third-party COA is for. Buy on documentation, not on brand adjacency.
What the research studies
The literature, not a summary of it.
GHRH-lineage pharmacology traces to Guillemin and Vale at the Salk Institute. Sermorelin-specific clinical work: Merriam, Cuttler, and the historical registration-trial literature sponsored by the original manufacturer. Journals: J Clin Endocrinol Metab, Growth Horm IGF Res, Endocr Rev. Read the research yourself:
Recommended vendor · Amino Club
≥ 99% by HPLC on the current lot — ILS Laboratories (ISO/IEC 17025).
$29.99 with Club pricing (was $59.99)
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