← Compare·GLP-1 family
Semaglutide vs Retatrutide.
These two bracket the family. Semaglutide is the single-receptor GLP-1 agonist that put the class on the map; retatrutide (LY3437943) sits at the far end as a triple agonist engaging the GIP, GLP-1, and glucagon receptors at once, and it is still investigational. Here is how the two ends line up on what is verifiable — structure, receptor targets, developer, regulatory status, and third-party documentation.
- Third-party tested
- ILS Laboratories · ISO/IEC 17025
- Lot-specific COA
Side by side — the verifiable facts
- Class
- Semaglutide: GLP-1 receptor agonist
- Retatrutide: GIP + GLP-1 + glucagon triple agonist
- Receptor target
- Semaglutide: GLP-1
- Retatrutide: GIP + GLP-1 + glucagon
- Agonism
- Semaglutide: Single agonist
- Retatrutide: Triple agonist
- Structure
- Semaglutide: 31-residue GLP-1 analog, C18 fatty-diacid chain
- Retatrutide: 39-residue peptide (LY3437943)
- Developer
- Semaglutide: Novo Nordisk
- Retatrutide: Eli Lilly
- Regulatory status
- Semaglutide: Approved INN
- Retatrutide: Investigational — not FDA-approved
- Third-party COA
- Semaglutide: ILS Labs · ISO/IEC 17025
- Retatrutide: ILS Labs · ISO/IEC 17025
- Vendor price
- Semaglutide: $49.99
- Retatrutide: From $69.99 (10MG)
The honest difference
What actually separates them.
One receptor versus three, and approved versus investigational — the widest gap in the family. Semaglutide is a 31-residue GLP-1 analog and an FDA-approved INN; retatrutide is a 39-residue triple agonist with published Phase-II data, Phase-III work still in progress, and no FDA approval. In both cases the published pharmacology describes a clinical molecule, and whether the research-grade compound in a given vial is that same molecule is what a lot-specific third-party COA is for. We link to Amino Club's ILS Laboratories (ISO/IEC 17025) COA library for each. Buy on documentation, not on brand adjacency.
Recommended vendor · Amino Club
Both ship from Amino Club, each with its own lot-specific COA.
- Third-party tested
- ILS Laboratories · ISO/IEC 17025
- Lot-specific COA
Flash sale at Amino Club — up to 50% off select research compounds, through Nov 8. Your purchase is tracked when you land through these links.
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