← Shelf·GLP-1 receptor agonist·I.
Semaglutide.
A 31-residue analog of human GLP-1 (~94% sequence homology) with a C18 fatty-diacid chain attached via a linker — the modification drives reversible albumin binding and extended plasma half-life. The GLP-1 receptor agonist researchers reference by this name.
GLP-1 is a hormone your gut makes after you eat. Native GLP-1 gets broken down in minutes; this is the long-circulating analog researchers study when they need the receptor engaged for a week at a time.
The most googled peptide of the decade. Almost none of what's written about it comes from journals. The literature is where the actual receptor pharmacology lives — the marketing lives everywhere else.
Straight talk
Straight talk: the receptor pharmacology is real and heavily published. Whether the research-grade compound in a given vial IS the same molecule as the FDA-approved drug of the same INN is exactly what a third-party COA is for. Buy on documentation, not on brand adjacency.
What the research studies
The literature, not a summary of it.
The primary literature spans Novo Nordisk clinical trials (Lau et al., Aroda, Marso), plus decades of upstream GLP-1 receptor pharmacology (Drucker, Holst, Nauck). Journals: NEJM, Lancet, Diabetes Care, Peptides, Nature Metabolism. Read the research yourself:
Recommended vendor · Amino Club
≥ 99% by HPLC on the current lot — ILS Laboratories (ISO/IEC 17025). Sold by Amino Club as GLP-1 (SM); the coded product name is the vendor's, the INN is ours for reference.
$32.49 during Fall Sale (was $49.99)
35% off applied automatically at checkout when you land through this link.